Bisacquino (Sicilian: Busacchinu) is a town and comune in the Province of Palermo in Sicily, Italy. It is located 82 km from Agrigento and currently has approximately 5,215 inhabitants.
The small town rises on an inner hill zone and is 663 metres above sea-level. The economy is based on agriculture and products are sold in abundance in the main town including cereals, olives, vegetables, almonds, hazel nuts and wine-grapes. Sheep breeding is also active in Bisacquino.
The name Bisacquino derives from an Arabic farm house “Busackuin” meaning “rich in waters”.
In the 12th century it was owned by local lords until 1778 when it became a property of the archbishop from Monreale. The Sanctuary of the Madonna of the Balzo near Mount Triona was erected in 1678.The main church is the Cathedral Church of Bisacquino which is dedicated to John the Baptist. It was built in 1713.
- The Italian-American film director Frank Capra (1897–1991) was born in Bisacquino
- Mafia boss Vito Cascioferro (1862–1945).